1.06 Protecting Group Manipulations in Carbohydrate Synthesis
نویسنده
چکیده
1.06.
منابع مشابه
Protecting groups in carbohydrate chemistry: influence on stereoselectivity of glycosylations.
Saccharides are polyhydroxy compounds, and their synthesis requires complex protecting group manipulations. Protecting groups are usually used to temporarily mask a functional group which may interfere with a certain reaction, but protecting groups in carbohydrate chemistry do more than protecting groups usually do. Particularly, protecting groups can participate in reactions directly or indire...
متن کامل2 Synthetic methods Part ( iii ) Protecting groups
Another excellent and comprehensive annual ‘update’ review of the 2000 literature relating to protecting group (PG) strategies in organic synthesis has appeared this year. The employment of PGs to direct ‘docking’ at oxidative enzyme active sites thereby controlling subsequent hydroxylation of unactivated carbon atoms has also been overviewed. Moreover, a summary of the use of microwave (MW) he...
متن کاملSimple one-pot regioselective 6-O-phosphorylation of carbohydrates and trehalose desymmetrization.
Biologically essential carbohydrate 6-phosphates, especially trehalose 6-phosphate, can be synthesized easily in excellent overall yields in 2 steps involving minimum protecting group manipulations. We can cleave the diphenylphosphate group for further synthetic objectives.
متن کاملCombinatorial chemoenzymatic strategies for in vitro glycorandomization: Efforts toward antibiotic optimization.
Extract: The natural product pool, which includes many glycosylated secondary metabolites, is the source of over half of the world's drug leads. For example, the antibiotics vancomycin and erythromycin, the antitumor compounds bleomycin and doxorubicin, and the antifungal agents amphotericin and nystatin all contain essential sugar attachments. Carbohydrate groups of natural product-based drugs...
متن کاملSynthesis of Fluorous Photolabile Aldehyde and Carbamate and Alkyl Carbamate Protecting Groups for Carbohydrate-Associated Amines
Two new fluorous photolabile-protecting groups (FNBC and FNB) and a new base-labile protecting group (FOC) for the masking of amines are reported. The protecting groups survive a wide range of common reaction conditions used in oligosaccharide synthesis and render the attached molecules amenable to fluorous solid-phase extraction (FSPE). A glycosyl acceptor containing the FNB group is shown to ...
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تاریخ انتشار 2007